Appel Reaction:

Appel Reaction

The Appel reaction is a common organic nucleophilic substitution reaction (SN2) employed to transform alcohol to a corresponding alkyl halide using the reagents tetrahalomethane (CX4) and triphenylphosphine (PPh4) with inversion of stereochemistry and high yield.

BIGINELLI REACTION:

biginelli reaction

The acid catalysed three-component one-pot synthesis of highly functionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) from biginelli reaction reactants heteroaromatic, aromatic and aliphatic aldehyde, urea, and ethyl acetoacetate.