Nef Reaction: Mechanism, Examples, Limitations


The reaction is general for primary Nitronates, which yield aldehydes, and secondary ones, which pay ketones. And in fact, the first reported example involved nitroethane in forming acetaldehyde. Although this is essentially a degradative reaction and not a skeleton-building reaction, a reactivity aspect makes the Nef reaction extremely useful.

The Henry Reaction

henry-reaction, Nitro-Aldol condensation

  The Henry reaction was first reported by Belgian chemist Louis Henry in 1895. The Henry reaction involves the addition of a nitronate salt to a carbonyl compound, usually an aldehyde. The reaction is also referred to as a Nitroaldol reaction. It is C-C bond-forming reaction used in organic synthesis.   Mechanism:   The Henry Reaction Mechanism can present in two steps … Read more