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what is the Prins reaction?
The Prins reaction is a acid catalyzed (protic and Lewis acid) condensation reaction of alkenes with aldehydes in presence of acid is referred to as the Prins reaction.
More than one product can formed in Prins reaction until careful control on the reaction protic and Lewis acid like H2SO4, HCl, HOCl, HNO3, p-TsOH, BF3, AlCl3, ZnCl2, TiCl4 can be used for catalysis. Reaction required the anhydrous conditions.
Prins reaction mechanism:
- Kriewitz, O. Additive compounds of formaldehyde with terpenes. Ber. 1899, 32, 57-60.
- Arundale, E., Mikeska, L. A. Chem. Rev. 1952, 51, 505-555.
- Marumoto, S., Jaber, J. J., Vitale, J. P., Rychnovsky, Org. Lett. 2002, 4, 3919-3922.
My name is Pradip Sanjay W. I’m an organic chemist originally from Maharashtra, India. I have qualified UGC NET-JRF, GATE in chemical sciences and MH-SET exam for assistant professor. I’m currently pursuing my Ph.D. in organic chemistry at the Indian Institute of Technology Hyderabad, India.