Prins reaction :

what is the Prins reaction?

The Prins reaction is a acid catalyzed (protic and Lewis acid) condensation reaction of alkenes with aldehydes in presence of acid is referred to as the Prins reaction.

More than one product can formed in Prins reaction until careful control on the reaction protic and Lewis acid like H2SO4, HCl, HOCl, HNO3, p-TsOH, BF3, AlCl3, ZnCl2, TiCl4 can be used for catalysis. Reaction required the anhydrous conditions.

Prins reaction image
Prins reaction.

Prins reaction mechanism:

prins reaction mechanism image
Prins reaction mechanism

Related reactions:

  1. Prins-pinacol rearrangement reaction

Reference :

  1. Kriewitz, O. Additive compounds of formaldehyde with terpenes. Ber. 1899, 32, 57-60.
  2. Arundale, E., Mikeska, L. A. Chem. Rev. 1952, 51, 505-555.
  3. Marumoto, S., Jaber, J. J., Vitale, J. P., Rychnovsky, Org. Lett. 2002, 4, 3919-3922.

1 thought on “Prins reaction :”

Leave a Comment