Alder Ene Reaction

The Alder Ene reaction, also known as the Alder-ene reaction or the ene reaction, is a type of pericyclic reaction in organic chemistry. It involves the addition of a π-bond (ene) to an unsaturated double bond (eneophile) in the presence of a Lewis acid or a transition metal catalyst. The reaction proceeds through a concerted mechanism, meaning that both the bond-making and bond-breaking steps occur simultaneously.

Alder-Ene Reaction Mechanism:

The Alder Ene reaction proceeds through a concerted pericyclic mechanism. The reaction involves the addition of a π-bond (ene) to an unsaturated double bond (eneophile) in the presence of a Lewis acid or a transition metal catalyst. Here’s a step-by-step explanation of the mechanism:

1. Activation:
2. Formation of the π-complex:
3. Approach and transition state formation:
4. Bond formation and bond breaking:
5. Product formation:

This concerted mechanism allows for the efficient formation of new carbon-carbon bonds and the synthesis of complex molecular structures in a single reaction.

Ene Reaction Examples :

This is an examples of alder ene reaction

Intramolecular Ene Reactions :

This is an intramolecular alder ene reaction

Ene Reaction in Pericyclic Reaction :

these are examples of ene reaction in pericyclic reactions

Related Reaction:

1. Diels-Alder reaction
2. Thiol-ene reaction
3. Prins Reaction

References :

1. Organic Chemistry Portal “
2. The Ene Reaction “
3. Alder-Ene Reaction “