Pauson-Khand Reaction

what is pauson-Khand reacction?

The Pauson-Khand reaction is an organic Multiple component reactions organic used to convert an alkyne and alkene to a substituted cyclopentenone by using CO2(CO)8 complex catalyst and an of carbon monoxide. Also known as Pauson-Khand cycloaddition.

pauson-khand reaction
pauson-khand reaction pdf

Pauson-Khand Reaction Mechanism :

This is 2+2+1 type of cycloaddition reaction, firstly it start with the addition of the alkyne to the Cobalt complex followed by ligand substitution of the alkene to expel a Carbon monoxide molecule. Alkene insertion follows and a subsequent Carbon monoxide insertion results in the formation of a carbonyl group then reductive eliminations then yield the final cyclopentenone product and regenerates the cobalt catalyst which will further repeat the catalytic process.

Related reactions:


  1. Cabot, R.; Lledó, A.; Revés, M.; Riera, A.; Verdaguer, X. Organometallics 2007, 26, 1134–1142.
  2. Yamanaka, M.; Nakamura, E. J. Am. Chem. Soc. 2001, 123, 1703–1708.
  3. Magnus, P.; Principe, L. M. Tetrahedron Letters 1985, 26, 4851–4854.

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