Aza-[2,3]-Wittig Rearrangement: Mechanism | Examples

The rearrangements reactions are important Name reaction in organic chemistry. Wittig rearrangement, first reported by G. Wittig and L. Löhmann in 1942, The Wittig rearrangement converts α-metalated ethers to metal alkoxides, yielding secondary or tertiary alcohols. Its nitrogen analog, the aza-Wittig rearrangement, transforms α-metalated tertiary amines into rearranged metal amides, producing homoallylic secondary amines. This … Read more

Aza-Claisen Rearrangement:

The Aza-Claisen rearrangement is a chemical reaction involving a nitrogen atom’s migration from one position to another within a molecule. It is named after the Claisen rearrangement, a well-known rearrangement reaction involving oxygen atoms. The mechanism of the aza-Claisen rearrangement: The mechanism of the aza-Claisen rearrangement involves three steps:  Protonation: The reaction often starts with … Read more

Schmidt Reaction (Rearrangement): definition| Mechanism| example

Schmidt Reaction for Synthesis of Nitrile and Amide

Schmidt reaction is a acid-catalyzed Rearrangement reaction of hydrazoic acid reactions of electrophiles, like carbonyl compounds, alkenes tertiary and alcohols. The following these substrates include amines, nitriles, amides or imines, rearrangement and extrusion of nitrogen.